Author: Li, Lv; Dai, Hong-Juan; Ye, Mao; Wang, Shu-Ling; Xiao, Xiao-Juan; Zheng, Jie; Chen, Hui-Yong; Luo, Yu-hao; Liu, Jing
Title: Lycorine induces cell-cycle arrest in the G0/G1 phase in K562 cells via HDAC inhibition Document date: 2012_11_23
ID: 13amcxh2_9
Snippet: Lycorine induces cell cycle arrest in the G0/G1 phase Inhibition of HDAC activity has been associated with cell-cycle arrest and growth inhibition. Thus, we determined whether or not lycorine can interfere with cell cycle progression by flow cytometry. After K562 cells were treated with 5 μM lycorine, the percentage of cells in the G0/G1 phase increased significantly from 35.9% to 41.9% while S-phase cells showed only a slight increased. The per.....
Document: Lycorine induces cell cycle arrest in the G0/G1 phase Inhibition of HDAC activity has been associated with cell-cycle arrest and growth inhibition. Thus, we determined whether or not lycorine can interfere with cell cycle progression by flow cytometry. After K562 cells were treated with 5 μM lycorine, the percentage of cells in the G0/G1 phase increased significantly from 35.9% to 41.9% while S-phase cells showed only a slight increased. The percentage of G2/M-phase cells decreased from 12.3% in the untreated group to 4.44% in the treated group ( Figure 3 ). This finding indicates that cell cycle distribution was blocked significantly in the G0/G1 phase when K562 cells are treated with lycorine.
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