Author: Li, Lv; Dai, Hong-Juan; Ye, Mao; Wang, Shu-Ling; Xiao, Xiao-Juan; Zheng, Jie; Chen, Hui-Yong; Luo, Yu-hao; Liu, Jing
Title: Lycorine induces cell-cycle arrest in the G0/G1 phase in K562 cells via HDAC inhibition Document date: 2012_11_23
ID: 13amcxh2_15
Snippet: Several studies have shown that inhibitors of HDAC block cell cycle progression at the G0/G1 or G2/M phase [17] depending on the cell type and type of drugs. Similar to the effect of HDAC inhibitors in other tumor types, lycorine inhibits cell cycle progression and induces cell-cycle arrest in the G0/G1 phase in K562 cells. Progress in the eukaryotic cell cycle is driven by protein kinase complexes consisting of a cyclin and a CDK. During G1-phas.....
Document: Several studies have shown that inhibitors of HDAC block cell cycle progression at the G0/G1 or G2/M phase [17] depending on the cell type and type of drugs. Similar to the effect of HDAC inhibitors in other tumor types, lycorine inhibits cell cycle progression and induces cell-cycle arrest in the G0/G1 phase in K562 cells. Progress in the eukaryotic cell cycle is driven by protein kinase complexes consisting of a cyclin and a CDK. During G1-phase progression, the complexes cyclin D-CDK4, cyclin D-CDK6, and cyclin E-CDK2 are activated and move the cell cycle from the G1 phase to the S phase. We found that cyclin D1, CDK4 and CDK2 are significantly downregulated in K562 cells after lycorine treatment. By contrast, the expression patterns of cyclin E, CDK2, and CDK6 were not significantly altered after lycorine treatment. This finding suggests that inhibition of cyclin D1 and CDK4 expression is involved in lycorine-induced G0/G1 arrest in K562 cells.
Search related documents:
Co phrase search for related documents- block cell cycle and cell cycle arrest: 1, 2, 3
- block cell cycle and cell cycle progression: 1, 2, 3
- block cell cycle and G0 G1 arrest: 1
- block cell cycle and G0 G1 phase: 1
- block cell cycle and G1 phase: 1
- block cell cycle and G1 phase cell cycle: 1
- block cell cycle progression and cell cycle: 1
- block cell cycle progression and cell cycle progression: 1
- CDK cyclin and cell cycle: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14
- CDK cyclin and cell cycle arrest: 1, 2, 3, 4, 5, 6, 7, 8
- CDK cyclin and cell cycle progression: 1, 2, 3, 4, 5
- CDK cyclin and cell cycle progression inhibit: 1
- CDK cyclin and eukaryotic cell cycle: 1
- CDK cyclin and G0 G1 arrest: 1, 2, 3
- CDK cyclin and G0 G1 phase: 1, 2, 3, 4, 5
- CDK cyclin and G1 phase: 1, 2, 3, 4, 5
- CDK cyclin and G1 phase cell cycle: 1
- cell cycle and expression pattern: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13
- cell cycle and HDAC inhibitor: 1, 2, 3, 4
Co phrase search for related documents, hyperlinks ordered by date