Author: Li, Lv; Dai, Hong-Juan; Ye, Mao; Wang, Shu-Ling; Xiao, Xiao-Juan; Zheng, Jie; Chen, Hui-Yong; Luo, Yu-hao; Liu, Jing
Title: Lycorine induces cell-cycle arrest in the G0/G1 phase in K562 cells via HDAC inhibition Document date: 2012_11_23
ID: 13amcxh2_16
Snippet: During G1-phase progression, pRB is phosphorylated by cyclin D-CDK4, CDK6, and cyclin E-CDK2 complexes. Hyperphosphorylation of pRB inactivates its function and dissociates the E2F transcription factor from pRB, which is critical to progression to the S phase. We found that, the expression level of pRB remains constant in lycorine-treated K562 cells, whereas the level of phosphorylated pRB decreases significantly, indicating that lycorine can sup.....
Document: During G1-phase progression, pRB is phosphorylated by cyclin D-CDK4, CDK6, and cyclin E-CDK2 complexes. Hyperphosphorylation of pRB inactivates its function and dissociates the E2F transcription factor from pRB, which is critical to progression to the S phase. We found that, the expression level of pRB remains constant in lycorine-treated K562 cells, whereas the level of phosphorylated pRB decreases significantly, indicating that lycorine can suppress pRB phosphorylation. Thus, hypophosphorylated pRB combines E2Fs more tightly, induces cell cycle arrest, and prevents proliferation.
Search related documents:
Co phrase search for related documents- cell cycle and phosphorylated prb: 1, 2
- cell cycle and phosphorylated prb level: 1
- cell cycle and prb expression level: 1
- cell cycle and pRB hyperphosphorylation: 1, 2
- cell cycle and prb phosphorylation: 1, 2, 3
- cell cycle and proliferation prevent: 1, 2
- cell cycle arrest and expression level: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14
- cell cycle arrest and phosphorylated prb: 1, 2
- cell cycle arrest and phosphorylated prb level: 1
- cell cycle arrest and prb expression level: 1
- cell cycle arrest and pRB hyperphosphorylation: 1
- cell cycle arrest and prb phosphorylation: 1, 2
- cell cycle arrest induce and expression level: 1, 2
- expression level and phosphorylated prb: 1, 2
- expression level and phosphorylated prb level: 1
- expression level and prb expression level: 1
- expression level and prb phosphorylation: 1
- expression level and significantly decrease: 1, 2, 3
- phosphorylated prb and prb expression level: 1
Co phrase search for related documents, hyperlinks ordered by date