Author: Lee, Yu-Ching; Tsai, Keng-Chang; Leu, Sy-Jye; Wang, Tuan-Jen; Liu, Chia-Yu; Yang, Yi-Yuan
Title: Isolation, Characterization, and Molecular Modeling of a Rheumatoid Factor from a Hepatitis C Virus Infected Patient with Sjögren's Syndrome Document date: 2013_12_30
ID: 0zsn4lu3_36
Snippet: In this study, we described the isolation and characterization of RFL11 Fab directed against human IgG Fc from a patient with Sjögren's syndrome and HCV infection. Being different from physiological RF arising from normal antibody responses to aid exogenous antigen clearance, these RFs may be involved in the pathogenesis of the patients with SS/HCV infection. The isolated IgG RF was proven to bind specifically to human IgG Fc fragment. The bindi.....
Document: In this study, we described the isolation and characterization of RFL11 Fab directed against human IgG Fc from a patient with Sjögren's syndrome and HCV infection. Being different from physiological RF arising from normal antibody responses to aid exogenous antigen clearance, these RFs may be involved in the pathogenesis of the patients with SS/HCV infection. The isolated IgG RF was proven to bind specifically to human IgG Fc fragment. The binding affinity was 6 × 10 −8 M, as determined by competitive inhibition assays ( Figure 4)
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