Author: Adedeji, Adeyemi O.; Marchand, Bruno; te Velthuis, Aartjan J. W.; Snijder, Eric J.; Weiss, Susan; Eoff, Robert L.; Singh, Kamalendra; Sarafianos, Stefan G.
Title: Mechanism of Nucleic Acid Unwinding by SARS-CoV Helicase Document date: 2012_5_15
ID: 1ssh296a_21
Snippet: Our long-term goal is to understand the mechanism of SARS-CoV replication and the specific contribution of nsp13, as a prerequisite for the development of antivirals. This study focused on the biochemical mechanism of SARS-CoV nsp13 and how it is affected by nsp12. Our results provide the first mechanistic glimpses into the functional interactions between key components of the SARS-CoV replication complex (RC) and allow comparisons with other RCs.....
Document: Our long-term goal is to understand the mechanism of SARS-CoV replication and the specific contribution of nsp13, as a prerequisite for the development of antivirals. This study focused on the biochemical mechanism of SARS-CoV nsp13 and how it is affected by nsp12. Our results provide the first mechanistic glimpses into the functional interactions between key components of the SARS-CoV replication complex (RC) and allow comparisons with other RCs.
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