Author: Warner, Nikole L.; Jokinen, Jenny D.; Beier, Juliane I.; Sokoloski, Kevin J.; Lukashevich, Igor S.
Title: Mammarenaviral Infection Is Dependent on Directional Exposure to and Release from Polarized Intestinal Epithelia Document date: 2018_2_10
ID: 1t8jmunt_2
Snippet: Lassa virus (LASV), the causative agent of Lassa fever (LF), is recognized as the most prevalent and most pathogenic of the OW arenaviruses. Annually in Western Africa, there are several hundred requires damage, layer such as from a scratch or bite from an infected host, to the epithelial cell layer [30] [31] [32] . Here, we investigated the interaction of LCMV-Arm, LCMV-WE, Mopeia virus (MOPV), and the LASV/MOPV reassortant ML-29 with polarized .....
Document: Lassa virus (LASV), the causative agent of Lassa fever (LF), is recognized as the most prevalent and most pathogenic of the OW arenaviruses. Annually in Western Africa, there are several hundred requires damage, layer such as from a scratch or bite from an infected host, to the epithelial cell layer [30] [31] [32] . Here, we investigated the interaction of LCMV-Arm, LCMV-WE, Mopeia virus (MOPV), and the LASV/MOPV reassortant ML-29 with polarized Caco-2 intestinal epithelial cells, to investigate the role of barrier systems in viral dissemination, and to further elucidate the interactions of OW mammarenaviruses with the gastrointestinal epithelial. Collectively, our current studies support the model that viral dissemination and interaction with epithelia may be host, tissue, and viral specific.
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