Author: Palmer, Duncan S.; Turner, Isaac; Fidler, Sarah; Frater, John; Goedhals, Dominique; Goulder, Philip; Huang, Kuan-Hsiang Gary; Oxenius, Annette; Phillips, Rodney; Shapiro, Roger; Vuuren, Cloete van; McLean, Angela R.; McVean, Gil
Title: Mapping the drivers of within-host pathogen evolution using massive data sets Document date: 2019_7_9
ID: 100r7w2n_25
Snippet: Note that the approximation of P (D 1 , D 2 , . . . , D n |Θ) using this HMM is dependent upon the ordering of {D 1 , D 2 , . . . , D k }. This is often resolved by randomly permuting the ordering some fixed number of times and determining an average [4] , or by letting the order be an unknown parameter [5] . Here we remove the ordering issue by considering each query sample independently......
Document: Note that the approximation of P (D 1 , D 2 , . . . , D n |Θ) using this HMM is dependent upon the ordering of {D 1 , D 2 , . . . , D k }. This is often resolved by randomly permuting the ordering some fixed number of times and determining an average [4] , or by letting the order be an unknown parameter [5] . Here we remove the ordering issue by considering each query sample independently.
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