Author: Ojosnegros, Samuel; Beerenwinkel, Niko
Title: Models of RNA virus evolution and their roles in vaccine design Document date: 2010_11_3
ID: 0q928h3b_7
Snippet: Because the diversity of the virus population can determine its evolutionary fate, selection seems to operate on the population level rather than at the level of individual viruses [11] . This idea was originally developed for selfreplicating RNA molecules and termed quasispecies theory [12] , and then applied to RNA viruses [13, 14] . One prediction of quasispecies theory is the existence of an upper bound on the mutation rate beyond which the p.....
Document: Because the diversity of the virus population can determine its evolutionary fate, selection seems to operate on the population level rather than at the level of individual viruses [11] . This idea was originally developed for selfreplicating RNA molecules and termed quasispecies theory [12] , and then applied to RNA viruses [13, 14] . One prediction of quasispecies theory is the existence of an upper bound on the mutation rate beyond which the population cannot maintain its essential genetic information. Many RNA viruses appear to have mutation rates close to this error threshold [9, 15, 16] .
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