Author: Li, Lv; Dai, Hong-Juan; Ye, Mao; Wang, Shu-Ling; Xiao, Xiao-Juan; Zheng, Jie; Chen, Hui-Yong; Luo, Yu-hao; Liu, Jing
Title: Lycorine induces cell-cycle arrest in the G0/G1 phase in K562 cells via HDAC inhibition Document date: 2012_11_23
ID: 13amcxh2_8
Snippet: Histone acetylation and deacetylation regulate the chromatin structure and gene transcription. Dysregulation of their function has been associated with human cancer development. Recent studies have utilized HDAC as a potential target for the development of new therapeutic agents [3] . To determine the effect of lycorine on HDACs, we detected the expression of HDAC1 and HDAC3 proteins in K562 cells after lycorine treatment. We found that lycorine .....
Document: Histone acetylation and deacetylation regulate the chromatin structure and gene transcription. Dysregulation of their function has been associated with human cancer development. Recent studies have utilized HDAC as a potential target for the development of new therapeutic agents [3] . To determine the effect of lycorine on HDACs, we detected the expression of HDAC1 and HDAC3 proteins in K562 cells after lycorine treatment. We found that lycorine did not change the expression of HDAC1 and HDAC3 proteins (data not shown), whereas lycorinetreated K562 cells significantly showed decreased HDAC activity of 24 h after treatment ( Figure 2 ). These results reveal that lycroine directly inhibits HDAC enzymatic activities but does not affect HDAC expression in K562 cells.
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