Author: Palmer, Duncan S.; Turner, Isaac; Fidler, Sarah; Frater, John; Goedhals, Dominique; Goulder, Philip; Huang, Kuan-Hsiang Gary; Oxenius, Annette; Phillips, Rodney; Shapiro, Roger; Vuuren, Cloete van; McLean, Angela R.; McVean, Gil
Title: Mapping the drivers of within-host pathogen evolution using massive data sets Document date: 2019_7_9
ID: 100r7w2n_124
Snippet: B * 07 epitope SPAIFQSSM (sites 156-164 in reverse transcriptase). We detect strong B * 07-dependent selection at the known escape site (position 162) [34, 35] . We also find two more top-tier sites and several second-tier sites within the epitope. On further investigation of the literature we find that many variants exist for this epitope, which result in non-susceptible forms in some individuals and susceptible forms in others [36] ......
Document: B * 07 epitope SPAIFQSSM (sites 156-164 in reverse transcriptase). We detect strong B * 07-dependent selection at the known escape site (position 162) [34, 35] . We also find two more top-tier sites and several second-tier sites within the epitope. On further investigation of the literature we find that many variants exist for this epitope, which result in non-susceptible forms in some individuals and susceptible forms in others [36] .
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