Author: Adedeji, Adeyemi O.; Marchand, Bruno; te Velthuis, Aartjan J. W.; Snijder, Eric J.; Weiss, Susan; Eoff, Robert L.; Singh, Kamalendra; Sarafianos, Stefan G.
Title: Mechanism of Nucleic Acid Unwinding by SARS-CoV Helicase Document date: 2012_5_15
ID: 1ssh296a_46
Snippet: To obtain the kinetic parameters associated with DNA unwinding by nsp13, the fraction of unwound DNA was plotted against time. Data fitting was carried out by non-linear regression using Dynafit 4.0 (BioKin Ltd, MA) Scientist 3.0 (Micromath), Prism 5.0 (GraphPad Inc.), and Kintec Explorer (Kintek Corporation, PA) software packages as described below. The fraction of ssDNA molecules formed after time 't', f ss (t) for an nstep unwinding mechanism .....
Document: To obtain the kinetic parameters associated with DNA unwinding by nsp13, the fraction of unwound DNA was plotted against time. Data fitting was carried out by non-linear regression using Dynafit 4.0 (BioKin Ltd, MA) Scientist 3.0 (Micromath), Prism 5.0 (GraphPad Inc.), and Kintec Explorer (Kintek Corporation, PA) software packages as described below. The fraction of ssDNA molecules formed after time 't', f ss (t) for an nstep unwinding mechanism [41] depicted in Fig. 1 is defined as:
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