Author: Garg, Anjali; Kumari, Bandana; Kumar, Ravindra; Kumar, Manish
Title: miPepBase: A Database of Experimentally Verified Peptides Involved in Molecular Mimicry Document date: 2017_10_23
ID: 06kffdm5_1
Snippet: Mimicry is a very common phenomenon in which a living being pretends to be what it is not. By adopting mimicry, an animal get protection by not hiding, rather being mistaken for something a predator will avoid because either it look dangerous or tastes bad. Hence, it is not surprising that similar strategy has been exploited at the molecular level as well. The obvious benefit molecular mimicry confers to pathogens is to fool the host's defenses a.....
Document: Mimicry is a very common phenomenon in which a living being pretends to be what it is not. By adopting mimicry, an animal get protection by not hiding, rather being mistaken for something a predator will avoid because either it look dangerous or tastes bad. Hence, it is not surprising that similar strategy has been exploited at the molecular level as well. The obvious benefit molecular mimicry confers to pathogens is to fool the host's defenses and survive. The presence of a molecule in a pathogen that is similar with a host antigen could inhibit the immune response of the host against the pathogen because of the immune tolerance toward self-antigens (Davies, 1997; Gowthaman and Eswarakumar, 2013) . For example, Helicobacter pylori infection in human triggers two autoimmune diseases namely autoimmune gastritis and pernicious anemia. It occurs because activated CD4 + Th1 cells infiltrates into gastric mucosa and they cross-recognize the self-epitopes of H + K + ATPase and H. pylori antigens (D'Elios et al., 2004) .
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