Author: Takhampunya, Ratree; Korkusol, Achareeya; Pongpichit, Chalermpol; Yodin, Komsan; Rungrojn, Artharee; Chanarat, Nitima; Promsathaporn, Sommai; Monkanna, Taweesak; Thaloengsok, Sasikanya; Tippayachai, Bousaraporn; Kumfao, Naruemon; Richards, Allen L.; Davidson, Silas A.
Title: Metagenomic Approach to Characterizing Disease Epidemiology in a Disease-Endemic Environment in Northern Thailand Document date: 2019_2_26
ID: 0gi6qzw0_58
Snippet: (dogs). Human granulocytic anaplasmosis (A. phagocytophilum) was also detected in rodents and their associated Ixodes ticks. Other anaplasmosis causative agents, A. bovis and A. platys were also detected from rodents and their ticks, and ticks of domesticated mammals. Interestingly, one UFI patient was positive for Anaplasma spp. with 96.8% identity to Uncultured Anaplasma spp. detected in a tick from China (GenBank accession No. KF728361.1). Eve.....
Document: (dogs). Human granulocytic anaplasmosis (A. phagocytophilum) was also detected in rodents and their associated Ixodes ticks. Other anaplasmosis causative agents, A. bovis and A. platys were also detected from rodents and their ticks, and ticks of domesticated mammals. Interestingly, one UFI patient was positive for Anaplasma spp. with 96.8% identity to Uncultured Anaplasma spp. detected in a tick from China (GenBank accession No. KF728361.1). Even though its identity to pathogenic species, A. phagocytophilum and A. bovis, was 92.3-92.7%, the phylogenetic relationship of its groEL sequence with these pathogenic species was relatively closer than other known species in the tree (online Supplementary Data). Borrelia miyamotoi was detected in one rodent (Niviventer spp.) with 99.6% identity to reference sequence of flagellin and 16S rRNA genes. Borrelia yangtzensis, a newly recognized B. valaisiana-like strain, was also found in one rodent and 2 tick pools collected from rodents (Ixodes spp.). Borrelia spp. detected in chiggers were sequenced and the results showed that only 2 sequences (16S rRNA gene) were highly similar to Borrelia species (97.4%) which were not grouped in any of 2 Borrelia groups; relapsing fever and Lyme. All five flaB sequences had very low identity to Borrelia species (68.0-79.2%) and were very distantly related to the genus of Borrelia as demonstrated by the phylogenetic tree analysis. The phylogenetic trees for most of pathogens detected were provided as online Supplementary Data.
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