Selected article for: "microarray screening and nerve injury"
Author: Connon, Richard E; Geist, Juergen; Pfeiff, Janice; Loguinov, Alexander V; D'Abronzo, Leandro S; Wintz, Henri; Vulpe, Christopher D; Werner, Inge
Title: Linking mechanistic and behavioral responses to sublethal esfenvalerate exposure in the endangered delta smelt; Hypomesus transpacificus (Fam. Osmeridae)
  • Document date: 2009_12_15
    • ID: 1ecqnstz_37
    Snippet: Heme is known to respond to nerve injury, and has been suggested to play a role in neurodegenerative disorders [72] , and hemopexin-mediated heme transport was reported to significantly decrease levels of transferrin receptor mRNA in HeLa cells [70] . Transferrin was also identified by microarray screening as significantly upregulated by esfenvalerate exposure. The primary role of transferrin is the delivery of iron across the blood brain barrier.....
    Document: Heme is known to respond to nerve injury, and has been suggested to play a role in neurodegenerative disorders [72] , and hemopexin-mediated heme transport was reported to significantly decrease levels of transferrin receptor mRNA in HeLa cells [70] . Transferrin was also identified by microarray screening as significantly upregulated by esfenvalerate exposure. The primary role of transferrin is the delivery of iron across the blood brain barrier, and its expression in brain is not only related to myelin production, but may be a permissive agent in the process of myelination [73] . Furthermore, hemopexin and transferrin reportedly act by similar receptor-mediated mechanisms [74] .

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