miPepBase: A Database of Experimentally Verified Peptides Involved in Molecular Mimicry

Garg, Anjali; Kumari, Bandana; Kumar, Ravindra; Kumar, Manish

Analysis of the miPepBase data shows that in both host and pathogen proteins more than one stretch of amino acids might be involved in molecular mimicry. The following information is associated with each entry: ID: It is a unique identifier assigned to each entry of the miPepBase database. Each ID is linked to the detailed information of that entry, which includes details of host and pathogen proteins, their gene ontology information, PDB ID of structure (if known), gene name, annotation status of protein (reviewed/not reviewed), PubMed ID, and remark (if any). Organism's name: With each event of molecular mimicry two different organisms are associated. Organism in which autoimmune response is generated was designated as host. Organism, which encodes the mimicry peptide, was designated as pathogen. Protein names: Two different proteins are associated with each event of molecular mimicry. One that is encoded by the host and second which is encoded by the pathogen. Names of both the proteins are present with each entry. Peptide sequence: This contains the stretch of amino acids (the peptide) present in both host's and pathogen's protein that actually leads to molecular mimicry. Pathogen taxonomic group: Organisms from all taxonomic groups such as bacteria, viruses, fungi, and protozoa exhibit molecular mimicry. MiPepBase contains information of molecular mimicry based autoimmunity events caused by organisms from all taxonomic groups.