Selected article for: "gene ontology and host pathogen protein"
Author: Garg, Anjali; Kumari, Bandana; Kumar, Ravindra; Kumar, Manish
Title: miPepBase: A Database of Experimentally Verified Peptides Involved in Molecular Mimicry
  • Document date: 2017_10_23
    • ID: 06kffdm5_22
    Snippet: Any data in miPepBase can be search and access by five different ways. It is illustrated here using one protein (UniProt accession number P10809). Users can get the information associated to this protein by querying miPepBase submission of UniProt accession number as a keyword to the "Keyword search option" (Figure 3A ) and click the search button (Step a1). The search result page showed a single hit and the information related to P10809 protein .....
    Document: Any data in miPepBase can be search and access by five different ways. It is illustrated here using one protein (UniProt accession number P10809). Users can get the information associated to this protein by querying miPepBase submission of UniProt accession number as a keyword to the "Keyword search option" (Figure 3A ) and click the search button (Step a1). The search result page showed a single hit and the information related to P10809 protein was presented in tabulated form. The search result contains following information: unique miPepBase ID (1217), host name (human), host protein name (HSP60), host mimicry peptide sequence (HRKPLVIIAEDVDGE), pathogen name (Mycobacterium bovis), pathogen protein name (HSP65), pathogen taxonomy (Gram positive bacteria), pathogen mimic sequence (AGKPLLIIAEDVEGE), and autoimmune disease (Rheumatoid arthritis) caused due to host and pathogen cross reactivity. All these details can also be downloaded as text file (Step a2). More detailed information related to P10809 can be retrieved through miPepBase ID of P10809 (i.e., 1,217, displayed in red font in the search table) (Step a3). Further, it will give more information about the host's and pathogen's: protein entry (host-P10809 and pathogen-P0A521), gene ontology (available for both), PDB ID (host-4PJ1 and pathogen-NA), gene name (host-HSPDI, HSP60 and pathogen-groL2, groEL2, groEL2, hsp65, Mb0448), protein reviewed (host-yes and pathogen-yes), immunological response (Helper T cell), PubMed ID (1577070), and remark (NA). In addition to these details the miPepBase also provide direct link to UniProt, EMBL-EBI, RCSB PDB, and PubMed. All information described above can also be downloaded as "Text File" (Step a6).

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