Author: Ojosnegros, Samuel; Beerenwinkel, Niko
Title: Models of RNA virus evolution and their roles in vaccine design Document date: 2010_11_3
ID: 0q928h3b_25
Snippet: The influenza vaccine needs to be redesigned regularly to account for genetic changes in the virus population. Normally, the changes are made in response to the antigenic drift of the virus. For example, between 1968 and 2001 the H3N2 component of the influenza vaccine was changed a total of 17 times [62] . The selection of viral strains to be included in the vaccine for the coming season is based on the antigenic properties of recent isolates, o.....
Document: The influenza vaccine needs to be redesigned regularly to account for genetic changes in the virus population. Normally, the changes are made in response to the antigenic drift of the virus. For example, between 1968 and 2001 the H3N2 component of the influenza vaccine was changed a total of 17 times [62] . The selection of viral strains to be included in the vaccine for the coming season is based on the antigenic properties of recent isolates, on epidemiological data, and on post-vaccination serological studies in humans.
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