Author: Ojosnegros, Samuel; Beerenwinkel, Niko
Title: Models of RNA virus evolution and their roles in vaccine design Document date: 2010_11_3
ID: 0q928h3b_3
Snippet: We also discuss current, approved experimental methodologies employed to the development of antiviral vaccines. Vaccine development deals with the four most important traits of viral evolution: virulence, fitness, diversity, and dynamics. Each one of these concepts has been subjected to intense studies but is still difficult to predict, probably because of the complexity of each trait and the intrinsic stochasticity of the evolutionary process. P.....
Document: We also discuss current, approved experimental methodologies employed to the development of antiviral vaccines. Vaccine development deals with the four most important traits of viral evolution: virulence, fitness, diversity, and dynamics. Each one of these concepts has been subjected to intense studies but is still difficult to predict, probably because of the complexity of each trait and the intrinsic stochasticity of the evolutionary process. Progress in understanding the interplay of these factors will depend on quantitative descriptions and predictive models. Thus, mathematical evolutionary modeling is likely to play an increasingly important role in the development of new vaccines and the control of viral disease.
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