Selected article for: "genetic diversity and high genetic diversity"
Author: Ojosnegros, Samuel; Beerenwinkel, Niko
Title: Models of RNA virus evolution and their roles in vaccine design
  • Document date: 2010_11_3
    • ID: 0q928h3b_31
    Snippet: Moreover, HIV has a great capacity for recombination among subtypes, and as a consequence, new circulating recombinant forms are constantly arising [89, 90] . Each subtype itself represents a great genetic diversity as well and even during infection of a single patient, HIV exists as an ensemble of different sequences [88] . The high genetic diversity of HIV populations hampers the development of a vaccine of broad applicability. Vaccine candidat.....
    Document: Moreover, HIV has a great capacity for recombination among subtypes, and as a consequence, new circulating recombinant forms are constantly arising [89, 90] . Each subtype itself represents a great genetic diversity as well and even during infection of a single patient, HIV exists as an ensemble of different sequences [88] . The high genetic diversity of HIV populations hampers the development of a vaccine of broad applicability. Vaccine candidates need to elicit responses against multiple epitopes in order to counteract the immune evasion by virus mutation [91, 92] .

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