Author: Ojosnegros, Samuel; Beerenwinkel, Niko
Title: Models of RNA virus evolution and their roles in vaccine design Document date: 2010_11_3
ID: 0q928h3b_47
Snippet: A viral infection is a complex molecular process, but it can be approximated by a few major steps ( Figure 2) . Initially, the virus needs to find a susceptible cell and enter into it. Once inside the cell, virus replication starts and viral offspring is released. Infected cells will eventually die. Released virus particles are either inactivated or they hit a new susceptible cell, in which case the infection cycle is closed and a chain reaction .....
Document: A viral infection is a complex molecular process, but it can be approximated by a few major steps ( Figure 2) . Initially, the virus needs to find a susceptible cell and enter into it. Once inside the cell, virus replication starts and viral offspring is released. Infected cells will eventually die. Released virus particles are either inactivated or they hit a new susceptible cell, in which case the infection cycle is closed and a chain reaction of sequential infections is triggered [144] [145] [146] . The dynamics of the viral replication cycle can be expressed in mathematical terms as follows:
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