Author: Ojosnegros, Samuel; Beerenwinkel, Niko
Title: Models of RNA virus evolution and their roles in vaccine design Document date: 2010_11_3
ID: 0q928h3b_5
Snippet: A quantitative description of viral evolution is necessary for monitoring the spread of viral pandemics and for developing effective therapies and vaccines [3] . Viruses are not only a threat to human health, but they also provide attractive model systems for evolutionary studies due to their short genomes, large population sizes, and high genetic diversity [4] . The extreme replication dynamics of RNA viruses, for example, allow for observing si.....
Document: A quantitative description of viral evolution is necessary for monitoring the spread of viral pandemics and for developing effective therapies and vaccines [3] . Viruses are not only a threat to human health, but they also provide attractive model systems for evolutionary studies due to their short genomes, large population sizes, and high genetic diversity [4] . The extreme replication dynamics of RNA viruses, for example, allow for observing significant evolutionary changes over time. Hypotheses and theories about evolutionary mechanisms can often be tested directly with these measurably evolving viruses [5] .
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