Author: Ojosnegros, Samuel; Beerenwinkel, Niko
Title: Models of RNA virus evolution and their roles in vaccine design Document date: 2010_11_3
ID: 0q928h3b_11
Snippet: Vaccine development can be considered one of the biggest achievements of modern medicine. While some bacterial families share common biochemical features, such as surface lipopolysacharide and therefore can be treated with common drugs or antibiotics [24] , viruses are typically different enough between families or even inside families, making the development of broadly applicable antiviral drugs challenging [2, 25] . For example, the base analog.....
Document: Vaccine development can be considered one of the biggest achievements of modern medicine. While some bacterial families share common biochemical features, such as surface lipopolysacharide and therefore can be treated with common drugs or antibiotics [24] , viruses are typically different enough between families or even inside families, making the development of broadly applicable antiviral drugs challenging [2, 25] . For example, the base analogue ribavirin alone or in combination with interferon, has been proven to act as an antiviral compound of broad activity in the clinical treatment of infections with hepatitis C virus (HCV), hepatitis B virus (HBV), and respiratory syncytial virus (RSV) [26] [27] [28] [29] [30] [31] .
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