Author: Ojosnegros, Samuel; Beerenwinkel, Niko
Title: Models of RNA virus evolution and their roles in vaccine design Document date: 2010_11_3
ID: 0q928h3b_40
Snippet: Phylogenetic dependency networks (PDNs) are a class of probabilistic graphical models that account for these confounding factors [123] . PDNs explicitly represent selection pressure from multiple sources and model the dependency structure among escape mutations conditioned on a phylogenetic tree of the observed viruses and on the HLA types of their hosts. By analyzing 1000 individuals from a multicenter cohort, the statistical model identified a .....
Document: Phylogenetic dependency networks (PDNs) are a class of probabilistic graphical models that account for these confounding factors [123] . PDNs explicitly represent selection pressure from multiple sources and model the dependency structure among escape mutations conditioned on a phylogenetic tree of the observed viruses and on the HLA types of their hosts. By analyzing 1000 individuals from a multicenter cohort, the statistical model identified a dense network of interactions between HLA alleles and HIV codons, as well as among HIV codons, reflecting the complexity but also the consistency of HIV adaptation to immune response [123] .
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