Author: Wysocki, Jan; Schulze, Arndt; Batlle, Daniel
Title: Novel Variants of Angiotensin Converting Enzyme-2 of Shorter Molecular Size to Target the Kidney Renin Angiotensin System Document date: 2019_12_17
ID: 0vozochc_42
Snippet: In this study, we describe the design and testing of novel recombinant mouse ACE2 proteins of a molecular size (~69-71 kD) much shorter than the native ACE2. The two short ACE2 variants are very active systemically, but of a molecular size short enough to render them filterable through the kidney glomerular filtration barrier. These short variants, moreover, are re-absorbable by the kidney tubules and thus capable of amplifying kidney ACE2 activi.....
Document: In this study, we describe the design and testing of novel recombinant mouse ACE2 proteins of a molecular size (~69-71 kD) much shorter than the native ACE2. The two short ACE2 variants are very active systemically, but of a molecular size short enough to render them filterable through the kidney glomerular filtration barrier. These short variants, moreover, are re-absorbable by the kidney tubules and thus capable of amplifying kidney ACE2 activity and fostering the formation of Ang 1-7 from Ang II. This feature should make them attractive to combat a vast array of kidney diseases where the RAS is over-active, such as acute kidney injury.
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