NUDT2 Disruption Elevates Diadenosine Tetraphosphate (Ap(4)A) and Down-Regulates Immune Response and Cancer Promotion Genes

Marriott, Andrew S.; Vasieva, Olga; Fang, Yongxiang; Copeland, Nikki A.; McLennan, Alexander G.; Jones, Nigel J.

Mixed results have been reported for a few of these DEGs in other contexts. For example, high expression of the cysteine-rich secretory protein CRISP3 (down 130-fold in NuKO cells) has been found in certain subtypes of prostate cancer [116] but down-regulation has been associated with oral squamous cell carcinoma [117] . A similar pattern has been found for the JCHAIN component of IgA and IgM (down 75-fold), which is up-regulated in prostate [108] but down-regulated in colorectal cancer [118] . The chemokine CXCL10 is another factor with both tumor-promoting and anti-tumor effects, the latter largely through its immunogenic action. It is overexpressed up to 40-fold in most types of cancer and can promote tumor cell growth and metastasis [119] but is down 66-fold in NuKO cells. Mixed results have also been reported for the Ig superfamily protein CD200 and the transmembrane co-receptor syndecan-4 (SDC4), with both pro-and anti-cancer roles suggested in different situations [120] [121] [122] . They are down 51-and up 35-fold in NuKO cells respectively.