Author: Yu, Liping; Zhang, Xiaorong; Wu, Tianqi; Su, Jin; Wang, Yuyang; Wang, Yuexin; Ruan, Baoyang; Niu, Xiaosai; Wu, Yantao
Title: Avian infectious bronchitis virus disrupts the melanoma differentiation associated gene 5 (MDA5) signaling pathway by cleavage of the adaptor protein MAVS Document date: 2017_11_13
ID: 0zn1sqj9_31
Snippet: A gene silencing technique was also used to identify whether chMDA5, chTLR3 and chMAVS influence the antiviral immune response mediated by IBV. First, to assess the effect of chMDA5, chTLR3 and chMAVS on IBV-induced IFN-β transcription, the expression of chMDA5, chTLR3 and chMAVS was knocked down. Compared with the control group, silencing of chMAVS or chMDA5 mRNA in DF1 cells significantly reduced IBV-induced IFN-β transcription. The simultane.....
Document: A gene silencing technique was also used to identify whether chMDA5, chTLR3 and chMAVS influence the antiviral immune response mediated by IBV. First, to assess the effect of chMDA5, chTLR3 and chMAVS on IBV-induced IFN-β transcription, the expression of chMDA5, chTLR3 and chMAVS was knocked down. Compared with the control group, silencing of chMAVS or chMDA5 mRNA in DF1 cells significantly reduced IBV-induced IFN-β transcription. The simultaneous silencing of chMDA5, chTLR3 and chMAVS reduced the transcription of IFN-β significantly (Fig. 7a) . These results suggest that both chMDA5 and chMAVS are involved in the activation of IFN-β in DF1 cells following IBV infection.
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