Author: Stark, Caren J; Atreya, CD
Title: Molecular advances in the cell biology of SARS-CoV and current disease prevention strategies Document date: 2005_4_15
ID: 0fitbwuv_12
Snippet: Successful viral replication depends upon the ability of the virus to subvert cellular processes to their advantage and counteract cellular defense mechanisms. Such viruscell interactions represent potential targets for the development of virus-specific antiviral drugs, therapeutics, and prophylactic vaccines. Different viruses, based on their target cell types and entry pathways, differ in their cellular exploitation mechanisms. The mechanism of.....
Document: Successful viral replication depends upon the ability of the virus to subvert cellular processes to their advantage and counteract cellular defense mechanisms. Such viruscell interactions represent potential targets for the development of virus-specific antiviral drugs, therapeutics, and prophylactic vaccines. Different viruses, based on their target cell types and entry pathways, differ in their cellular exploitation mechanisms. The mechanism of SARS virus pathogenesis in vivo may reflect both the effect of viral replication in target cells and host immune responses. The molecular basis for SARS-CoV replication, the signaling pathways affected, and the inflammatory responses provoked by viral infection are not yet clearly understood. Progress in these areas should lead to more effective preventive strategies to counter SARS-CoV infections.
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