Selected article for: "cell surface and virus cell"
Author: Stark, Caren J; Atreya, CD
Title: Molecular advances in the cell biology of SARS-CoV and current disease prevention strategies
  • Document date: 2005_4_15
    • ID: 0fitbwuv_19
    Snippet: The balance of cell survival and cell death in response to SARS-CoV infection Figure 1 The balance of cell survival and cell death in response to SARS-CoV infection. SARS-CoV is shown approaching a cell with ACE2 receptors (blue "Y"s) on the surface. The virus enters the cell, uncoats, and the viral RNA is replicated and translated. The SARS-CoV U122 protein induces apoptosis in cells. SARS-CoV S and N proteins each can activate the cellular AP-1.....
    Document: The balance of cell survival and cell death in response to SARS-CoV infection Figure 1 The balance of cell survival and cell death in response to SARS-CoV infection. SARS-CoV is shown approaching a cell with ACE2 receptors (blue "Y"s) on the surface. The virus enters the cell, uncoats, and the viral RNA is replicated and translated. The SARS-CoV U122 protein induces apoptosis in cells. SARS-CoV S and N proteins each can activate the cellular AP-1 protein, which regulates apoptosis, as well as other cellular processes. AP-1 also activates IL-8, a cellular cytokine. SARS-CoV infection induces both MAPK (pro-apoptotic) and Akt (anti-apoptotic) pathways. How this balance between cell survival and apoptosis is maintained is yet unknown. Cellular proteins are labeled in blue, viral proteins in black.

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