Author: Zivcec, Marko; Scholte, Florine E. M.; Spiropoulou, Christina F.; Spengler, Jessica R.; Bergeron, Éric
Title: Molecular Insights into Crimean-Congo Hemorrhagic Fever Virus Document date: 2016_4_21
ID: 0a20s62q_10
Snippet: The replication of genomic RNPs is a process requiring the replication and encapsidation of uncapped, negative sense vRNA and positive sense complementary RNA (cRNA). The replication of the RNPs minimally require the L protein and NP [26] . The encapsidated forms of the cRNA and vRNA are respectively defined as antigenomic and genomic RNPs ( Figure 1 ). Since CCHFV is a negative strand RNA virus, genomic RNPs are used as template to synthesize ca.....
Document: The replication of genomic RNPs is a process requiring the replication and encapsidation of uncapped, negative sense vRNA and positive sense complementary RNA (cRNA). The replication of the RNPs minimally require the L protein and NP [26] . The encapsidated forms of the cRNA and vRNA are respectively defined as antigenomic and genomic RNPs ( Figure 1 ). Since CCHFV is a negative strand RNA virus, genomic RNPs are used as template to synthesize capped mRNA and produce antigenomic RNPs. During the replication of the genomic RNPs, a cRNA is synthesized by the L protein and NP subunits are added to the elongating strands to obtain antigenomic RNPs, and in turn the cRNA of the antigenomic RNPs is used a template to obtain genomic RNPs.
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