Author: Zivcec, Marko; Scholte, Florine E. M.; Spiropoulou, Christina F.; Spengler, Jessica R.; Bergeron, Éric
Title: Molecular Insights into Crimean-Congo Hemorrhagic Fever Virus Document date: 2016_4_21
ID: 0a20s62q_34
Snippet: CCHFV reverse genetics systems are powerful tools for investigating underlying mechanisms of the viral replication cycle, host immune evasion, and numerous other pathogen-host interactions. These systems are particularly useful for dissecting and studying the basics of the viral replication cycle, including viral genome transcription, replication, particle assembly and egress. In addition, reverse genetics enables the generation of reporter virus.....
Document: CCHFV reverse genetics systems are powerful tools for investigating underlying mechanisms of the viral replication cycle, host immune evasion, and numerous other pathogen-host interactions. These systems are particularly useful for dissecting and studying the basics of the viral replication cycle, including viral genome transcription, replication, particle assembly and egress. In addition, reverse genetics enables the generation of reporter viruses and allows mutational analyses, for example when studying viral drug resistance or pinpointing catalytic residues.
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