Molecular Insights into Crimean-Congo Hemorrhagic Fever Virus

Zivcec, Marko; Scholte, Florine E. M.; Spiropoulou, Christina F.; Spengler, Jessica R.; Bergeron, Éric

RNP replication is followed, and later accompanied, by viral protein processing and subsequent maturation. The maturation of CCHFV GPC is unusually complex and shares little similarity with glycoprotein processing in other bunyaviruses [31] . GPC maturation yields the structural glycoproteins Gn and Gc; secreted non-structural proteins GP160, GP85, and GP38 [31, 51] ; and the non-structural M protein (NS M ) [52] (Figure 3 ). Nairoviruses are the only bunyaviruses known to encode secreted non-structural glycoproteins [31, 37, [52] [53] [54] [55] [56] [57] . To yield the complete set of glycoproteins, the GPC is heavily glycosylated [31] and subsequently cleaved by host proteases including the proprotein convertases [51, 54, 56, 58] , a family of mammalian serine proteases known to process a variety of cellular proteins, viral glycoproteins, and bacterial toxins [59] .