Selected article for: "CCHFV assembly and ER productive maturation"
Author: Zivcec, Marko; Scholte, Florine E. M.; Spiropoulou, Christina F.; Spengler, Jessica R.; Bergeron, Éric
Title: Molecular Insights into Crimean-Congo Hemorrhagic Fever Virus
  • Document date: 2016_4_21
    • ID: 0a20s62q_14
    Snippet: The productive maturation in the ER is followed by PreGn and PreGc transport to the Golgi complex [52, 54] , where the PreGn mucin-like domain (MLD) acquire numerous O-linked glycans [51] . PreGn can traffic to the Golgi complex, the proposed site of CCHFV assembly, in the absence of PreGc [37] , but PreGc requires PreGn to exit the ER [37] . Mutating the N577 glycosylation site of PreGn, located in the mature Gn region, blocks PreGn from exiting.....
    Document: The productive maturation in the ER is followed by PreGn and PreGc transport to the Golgi complex [52, 54] , where the PreGn mucin-like domain (MLD) acquire numerous O-linked glycans [51] . PreGn can traffic to the Golgi complex, the proposed site of CCHFV assembly, in the absence of PreGc [37] , but PreGc requires PreGn to exit the ER [37] . Mutating the N577 glycosylation site of PreGn, located in the mature Gn region, blocks PreGn from exiting the ER and prevents secretion of GP160, GP85, and GP38, suggesting a critical role for the glycosylation of N577 in folding and normal trafficking to the Golgi complex [55] .

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