Selected article for: "cellular viral membrane and virus entry"
Author: Xudan Chen; Yang Zhang; Baoyi Zhu; Jianwen Zeng; Wenxin Hong; Xi He; Jingfeng Chen; Haipeng Zheng; Shuang Qiu; Ying Deng; Juliana Chan; Jian Wang
Title: Associations of clinical characteristics and antiviral drugs with viral RNA clearance in patients with COVID-19 in Guangzhou, China: a retrospective cohort study
  • Document date: 2020_4_14
    • ID: 9j4ese89_30
    Snippet: Arbidol is an antiviral drug approved in Russia and China for treating influenza. It acts against influenza A and B by inhibiting viral fusion with cellular membrane and blocking the virus entry into host cells [23] . In a retrospective cohort study, arbidol accelerated the clearance of viral RNA in patients with COVID-19 compared to empirical treatment [14] . In China, it has been recommended as one of the antiviral drugs for COVID-19 [11] . Ose.....
    Document: Arbidol is an antiviral drug approved in Russia and China for treating influenza. It acts against influenza A and B by inhibiting viral fusion with cellular membrane and blocking the virus entry into host cells [23] . In a retrospective cohort study, arbidol accelerated the clearance of viral RNA in patients with COVID-19 compared to empirical treatment [14] . In China, it has been recommended as one of the antiviral drugs for COVID-19 [11] . Oseltamivir is another drug approved for the treatment of influenza A and B [24], and has been used in some patients with COVID-19 [3, 7] . In this study, neither arbidol nor oseltamivir exhibited positive effects on the viral RNA clearance of COVID-19. Further, the combination of arbidol with another antiviral drug, oseltamivir or lopinavir/ritonavir, tended to delay clearance of viral RNA. All rights reserved. No reuse allowed without permission.

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