Author: Dai, Xiaofeng; Hakizimana, Olivier; Zhang, Xuanhao; Kaushik, Aman Chandra; Zhang, Jianying
Title: Orchestrated efforts on host network hijacking: Processes governing virus replication Document date: 2020_2_12
ID: 1dc46btc_31
Snippet: One important factor leading to cell cycle arrest that is worth underpinning is DNA damage (Figure 4 ). DNA damage transfers stress signals via viral proteins or viral genome and causes altered expression of stress-responsive proteins such as TP53 as well as cell cycle regulatory proteins such as CDK inhibitors. For instance, adenoassociated viruses (AAV) could induce the G2/M arrest by activating DNA damage responses [109] ; HCVs hijacks the DNA.....
Document: One important factor leading to cell cycle arrest that is worth underpinning is DNA damage (Figure 4 ). DNA damage transfers stress signals via viral proteins or viral genome and causes altered expression of stress-responsive proteins such as TP53 as well as cell cycle regulatory proteins such as CDK inhibitors. For instance, adenoassociated viruses (AAV) could induce the G2/M arrest by activating DNA damage responses [109] ; HCVs hijacks the DNA damage response signal, sequesters and relocalizes CDK2 interacting protein (CINP) that is responsible for genomic maintenance from the nucleus to cytoplasm via the NS5B viral protein, and this consequently leads to cell S phase delay [110] ; and Epstein-Barr viruses induce TP53-mediated G0/G1 arrest in response to DNA damage via the bZIP transcription factor Zta [111] .
Search related documents:
Co phrase search for related documents- alter expression and cell cycle: 1, 2, 3
- alter expression and cell cycle arrest: 1
- alter expression and dna damage: 1, 2, 3
- alter expression and Epstein Barr virus: 1
- alter expression and important factor: 1
- bzip transcription factor and Epstein Barr virus: 1
- CDK inhibitor and cell cycle: 1, 2
- CDK inhibitor and cell cycle arrest: 1, 2
- cell cycle and dna damage: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- cell cycle and dna damage response: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
- cell cycle and Epstein Barr virus: 1, 2, 3, 4, 5, 6, 7, 8
- cell cycle and G0 G1 arrest: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- cell cycle and G0 G1 arrest induce: 1, 2, 3
- cell cycle and important factor: 1, 2, 3, 4, 5, 6, 7, 8
- cell cycle and interact protein: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12
- cell cycle arrest and Epstein Barr virus: 1, 2, 3
- cell cycle arrest and G0 G1 arrest induce: 1, 2, 3
- cell cycle arrest and important factor: 1
- cell cycle arrest and interact protein: 1
Co phrase search for related documents, hyperlinks ordered by date