Author: Zivcec, Marko; Scholte, Florine E. M.; Spiropoulou, Christina F.; Spengler, Jessica R.; Bergeron, Éric
Title: Molecular Insights into Crimean-Congo Hemorrhagic Fever Virus Document date: 2016_4_21
ID: 0a20s62q_43
Snippet: CCHF is a medically important tick-borne disease with a wide endemic distribution. At present, antiviral strategies to treat human CCHFV infection remain controversial or experimental. The most widely used antiviral, Ribavirin, has been shown to be effective against CCHFV in vitro and in animal models, but its clinical benefit remains unproven [114] [115] [116] . Although significant advances have been made in the field in recent years, many aspe.....
Document: CCHF is a medically important tick-borne disease with a wide endemic distribution. At present, antiviral strategies to treat human CCHFV infection remain controversial or experimental. The most widely used antiviral, Ribavirin, has been shown to be effective against CCHFV in vitro and in animal models, but its clinical benefit remains unproven [114] [115] [116] . Although significant advances have been made in the field in recent years, many aspects of the CCHFV replicative cycle and pathogenesis still remain poorly defined. Additional studies to improve our knowledge of all viral proteins are warranted. Structural and/or sequence similarities of the CCHFV NP to the NP of related, better-studied arenaviruses may help to predict the putative functions of the CCHFV NP domains and guide future research. The advent of more advanced molecular tools to study NP in the context of a viral infection has the potential to greatly enhance our understanding of the roles of NP and the potential differences between various CCHFV genotypes.
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