Author: Zivcec, Marko; Scholte, Florine E. M.; Spiropoulou, Christina F.; Spengler, Jessica R.; Bergeron, Éric
Title: Molecular Insights into Crimean-Congo Hemorrhagic Fever Virus Document date: 2016_4_21
ID: 0a20s62q_6
Snippet: After attaching to the cell surface, CCHFV is endocytosed through a clathrin-mediated endocytosis mechanism. Entry requires clathrin and the clathrin pit adaptor protein-2 complex, but not caveolin-1 [45] [46] [47] . CCHFV entry is also dependent on cholesterol and a low pH [45, 46] . Following endocytosis CCHFV particles are transported to early endosomes and subsequently to multivesicular bodies (MVB) in a process that is dependent on Rab5 [46,.....
Document: After attaching to the cell surface, CCHFV is endocytosed through a clathrin-mediated endocytosis mechanism. Entry requires clathrin and the clathrin pit adaptor protein-2 complex, but not caveolin-1 [45] [46] [47] . CCHFV entry is also dependent on cholesterol and a low pH [45, 46] . Following endocytosis CCHFV particles are transported to early endosomes and subsequently to multivesicular bodies (MVB) in a process that is dependent on Rab5 [46, 47] .
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