Multiplex PCR point of care testing versus routine, laboratory-based testing in the treatment of adults with respiratory tract infections: a quasi-randomised study assessing impact on length of stay and antimicrobial use

Andrews, Denise; Chetty, Yumela; Cooper, Ben S.; Virk, Manjinder; Glass, Stephen K; Letters, Andrew; Kelly, Philip A.; Sudhanva, Malur; Jeyaratnam, Dakshika

We found no association between respiratory multiplex PCR (BioFire FilmArray®) POC testing and length of hospital stay when compared to our routine, laboratorybased respiratory PCR and serology testing. This result was most likely influenced by the delay in the rapid POC testing. POC testing produced results considerably faster than the routine tests but the results were not rapid as designed to be. This was not the fault of the POC test, but highlights the fact that new technology itself is not enough: the correct systems must be in place in order to reap their benefits. Patients who had the POC test received time-critical antivirals for influenza significantly faster and appropriate therapy for mycoplasma infection, not seen in the control arm. Ward staff of all grades performed the POC test without incident meaning that this test has potential across a range of healthcare. Further studies are required that focus on implementing respiratory multiplex PCR POC testing with rapid results, in order to fully assess the impact on length of stay and antibiotic use.