Author: Vega, Vinsensius B; Ruan, Yijun; Liu, Jianjun; Lee, Wah Heng; Wei, Chia Lin; Se-Thoe, Su Yun; Tang, Kin Fai; Zhang, Tao; Kolatkar, Prasanna R; Ooi, Eng Eong; Ling, Ai Ee; Stanton, Lawrence W; Long, Philip M; Liu, Edison T
Title: Mutational dynamics of the SARS coronavirus in cell culture and human populations isolated in 2003 Document date: 2004_9_6
ID: 0gmtnkbh_14
Snippet: In the estimation of SARS-CoV daily mutation rate, we employed the conservative constant mutation rate model [9] , where the number of mutations d found in an isolate from its ancestor is proportional to the mutation rate k and the temporal difference t between the isolate and its ancestor, so that d = k × t. Based on the Singapore patients contact tracing information (see Figure 4 ), we obtained 6 pairs of isolates with known definite ancestor-.....
Document: In the estimation of SARS-CoV daily mutation rate, we employed the conservative constant mutation rate model [9] , where the number of mutations d found in an isolate from its ancestor is proportional to the mutation rate k and the temporal difference t between the isolate and its ancestor, so that d = k × t. Based on the Singapore patients contact tracing information (see Figure 4 ), we obtained 6 pairs of isolates with known definite ancestor-descendant relationship, calculated the number of mutations (d) and the time difference (t) for each pair, and estimate the mutation rate k for the model using least square fitting. The goodness-of-fit were measured using the adjusted Rsquare statistics.
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