Author: Yong, Kylie Su Mei; Ng, Justin Han Jia; Her, Zhisheng; Hey, Ying Ying; Tan, Sue Yee; Tan, Wilson Wei Sheng; Irac, Sergio Erdal; Liu, Min; Chan, Xue Ying; Gunawan, Merry; Foo, Randy Jee Hiang; Low, Dolyce Hong Wen; Mendenhall, Ian Hewitt; Chionh, Yok Teng; Dutertre, Charles-Antoine; Chen, Qingfeng; Wang, Lin-Fa
Title: Bat-mouse bone marrow chimera: a novel animal model for dissecting the uniqueness of the bat immune system Document date: 2018_3_16
ID: 01f36rld_4
Snippet: In this study, we adopted the concept of humanized mouse models 24 and aimed to stably reproduce bat's biological system, particularly the immune system, in mice, by transplanting bat cells (Eonycteris spelaea) into immunodeficient mouse strain NOD-scid IL-2Rγ −/− (NSG) mice (bat-mice). In this bat-mouse model, bat immune cells were successfully reconstituted in mice and unique features, such as resistance to graft rejection and functional d.....
Document: In this study, we adopted the concept of humanized mouse models 24 and aimed to stably reproduce bat's biological system, particularly the immune system, in mice, by transplanting bat cells (Eonycteris spelaea) into immunodeficient mouse strain NOD-scid IL-2Rγ −/− (NSG) mice (bat-mice). In this bat-mouse model, bat immune cells were successfully reconstituted in mice and unique features, such as resistance to graft rejection and functional demonstration of antigen-specific bat antibody responses have been observed and characterized.
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