Author: McCarthy, Mary K.; Reynoso, Glennys V.; Winkler, Emma S.; Mack, Matthias; Diamond, Michael S.; Hickman, Heather D.; Morrison, Thomas E.
Title: MyD88-dependent influx of monocytes and neutrophils impairs lymph node B cell responses to chikungunya virus infection via Irf5, Nos2 and Nox2 Document date: 2020_1_30
ID: 1tut4erh_17
Snippet: We next investigated the molecular pathways by which monocytes and neutrophils are recruited into the dLN following pathogenic CHIKV infection. Recruitment of Ly6C hi monocytes to inflamed tissue or the dLN in response to viral infection is reportedly CCR2-and type I IFN-dependent [5, 29] . Accordingly, we first investigated the role of type I IFN signaling in combined from 3 independent experiments. Data in (K) are representative of 2 independen.....
Document: We next investigated the molecular pathways by which monocytes and neutrophils are recruited into the dLN following pathogenic CHIKV infection. Recruitment of Ly6C hi monocytes to inflamed tissue or the dLN in response to viral infection is reportedly CCR2-and type I IFN-dependent [5, 29] . Accordingly, we first investigated the role of type I IFN signaling in combined from 3 independent experiments. Data in (K) are representative of 2 independent experiments with 4-5 LNs per group. Statistical significance was determined by one-way ANOVA with Tukey's post-test ( � , P < 0.05; �� , P < 0.01; ��� , P < 0.001).
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