Author: Colino, Clara I.; Millán, Carmen Gutiérrez; Lanao, José M.
Title: Nanoparticles for Signaling in Biodiagnosis and Treatment of Infectious Diseases Document date: 2018_5_31
ID: 1bxwb2hj_148
Snippet: The insolubility of many molecules that are inhibitors of QS limit their potential to be used as drugs [131] . Recently, a PqsR antagonist, thus linked to the PQS signal: 2-heptyl-6-nitro-4-oxo-1,4-dihydroquinoline-3-carboxamide, was described as strongly inhibiting the virulence of Pseudomonas aeruginosa. As it is a very lipophilic molecule, it was formulated in solid lipid nanoparticles (SLN) and the anti-QS activity was evaluated. It was found.....
Document: The insolubility of many molecules that are inhibitors of QS limit their potential to be used as drugs [131] . Recently, a PqsR antagonist, thus linked to the PQS signal: 2-heptyl-6-nitro-4-oxo-1,4-dihydroquinoline-3-carboxamide, was described as strongly inhibiting the virulence of Pseudomonas aeruginosa. As it is a very lipophilic molecule, it was formulated in solid lipid nanoparticles (SLN) and the anti-QS activity was evaluated. It was found that the loaded NPs were superior to the free QSI in the inhibition of pyocianin formation. Also, a strong inhibition of this virulence factor was achieved with plain SLN. This effect was not due to the killing of bacteria and was attributed to the emulsifiers present in the formulation, mainly Tween 80 and Poloxamer 407 [202] .
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