Author: Colino, Clara I.; Millán, Carmen Gutiérrez; Lanao, José M.
Title: Nanoparticles for Signaling in Biodiagnosis and Treatment of Infectious Diseases Document date: 2018_5_31
ID: 1bxwb2hj_53
Snippet: Immunoassay methodology using small molecules as a substitute for antibodies with a strong affinity to the bacteria, such as certain antibiotics, have been proposed. Vancomycin is a glycopeptide antibiotic with affinity to gram-positive bacteria due to the multivalent hydrogen binding effect. Mesoporous silica nanoparticles modified with vancomycin have been developed for the recognition and killing of Gram-positive bacteria. Mesopores of vancomy.....
Document: Immunoassay methodology using small molecules as a substitute for antibodies with a strong affinity to the bacteria, such as certain antibiotics, have been proposed. Vancomycin is a glycopeptide antibiotic with affinity to gram-positive bacteria due to the multivalent hydrogen binding effect. Mesoporous silica nanoparticles modified with vancomycin have been developed for the recognition and killing of Gram-positive bacteria. Mesopores of vancomycin silica nanoparticles were loaded with a fluorescent molecule (FITC). After incubation with FITC and bacteria, the detection was performed by measuring the fluorescence with high specificity and sensitivity. With this method, the detection and killing of Gram-positive bacteria such as S. aureus was performed [60] .
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