Author: Yang, Liu; Du, Xing; Liu, Lu; Cao, Qiuyu; Pan, Zengxiang; Li, Qifa
Title: miR-1306 Mediates the Feedback Regulation of the TGF-ß/SMAD Signaling Pathway in Granulosa Cells Document date: 2019_3_31
ID: 16qix4ab_4
Snippet: In our previous study, we demonstrated that miR-425 interacts with the classical TGF-β/SMAD signaling pathway by directly targeting TGFBR2 and suppressing its expression in granulosa cells (GCs) of the porcine ovary [9] . However, further investigation was required to understand the regulatory role of miRNAs in TGFBR2 expression in GCs. In this study, we isolated and characterized the 3 -untranslated region (UTR) of the porcine TGFBR2 gene and f.....
Document: In our previous study, we demonstrated that miR-425 interacts with the classical TGF-β/SMAD signaling pathway by directly targeting TGFBR2 and suppressing its expression in granulosa cells (GCs) of the porcine ovary [9] . However, further investigation was required to understand the regulatory role of miRNAs in TGFBR2 expression in GCs. In this study, we isolated and characterized the 3 -untranslated region (UTR) of the porcine TGFBR2 gene and further identified the potential miRNAs that target TGFBR2 in GCs. Our findings provide additional evidence of epigenetic mechanisms that regulate the TGF-β signaling pathway in GCs.
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