Selected article for: "BBB disruption and post stroke BBB disruption"
Author: O’Connell, Grant C.; Treadway, Madison B.; Petrone, Ashley B.; Tennant, Connie S.; Lucke-Wold, Noelle; Chantler, Paul D.; Barr, Taura L.
Title: Peripheral blood AKAP7 expression as an early marker for lymphocyte-mediated post-stroke blood brain barrier disruption
  • Document date: 2017_4_26
    • ID: 1ey6ie95_9_1
    Snippet: we observed between the expression levels of the PKA-binding AKAP7 splice variants and the expression levels of ITGA3 exists because these AKAP7 isoforms mediate the interaction between ITGA3 and PKA. Interestingly, elevated expression of ITGA3 is associated with lymphocyte invasiveness 30, 31 , and inhibition of ITGA3 has been to shown to limit leukocyte extravasation in inflammatory conditions such as sepsis 19 . In light of our observations, t.....
    Document: we observed between the expression levels of the PKA-binding AKAP7 splice variants and the expression levels of ITGA3 exists because these AKAP7 isoforms mediate the interaction between ITGA3 and PKA. Interestingly, elevated expression of ITGA3 is associated with lymphocyte invasiveness 30, 31 , and inhibition of ITGA3 has been to shown to limit leukocyte extravasation in inflammatory conditions such as sepsis 19 . In light of our observations, this information led us to hypothesize that the PKA-binding isoforms of AKAP7 are markers of ITGA3-mediated lymphocyte adhesiveness, and are likely elevated in patients who later develop post-stroke BBB disruption as a result of the presence of an invasive lymphocyte population in the peripheral blood.

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