Author: Ferreira, Anderson J.; Murça, Tatiane M.; Fraga-Silva, Rodrigo A.; Castro, Carlos Henrique; Raizada, Mohan K.; Santos, Robson A. S.
Title: New Cardiovascular and Pulmonary Therapeutic Strategies Based on the Angiotensin-Converting Enzyme 2/Angiotensin-(1–7)/Mas Receptor Axis Document date: 2012_1_26
ID: 0qkzd2w4_1
Snippet: The renin-angiotensin system (RAS) plays a key role in several target organs, such as heart, blood vessels, and lungs, exerting a powerful control in the maintenance of the homeostasis [1] [2] [3] [4] . This system is activated by the conversion of the angiotensinogen to the inactive peptide angiotensin (Ang) I through the renin action [5] . Subsequently, Ang I is cleaved by the angiotensin-converting enzyme (ACE) generating Ang-(1-7) by ACE2 is .....
Document: The renin-angiotensin system (RAS) plays a key role in several target organs, such as heart, blood vessels, and lungs, exerting a powerful control in the maintenance of the homeostasis [1] [2] [3] [4] . This system is activated by the conversion of the angiotensinogen to the inactive peptide angiotensin (Ang) I through the renin action [5] . Subsequently, Ang I is cleaved by the angiotensin-converting enzyme (ACE) generating Ang-(1-7) by ACE2 is important to regulate the RAS activity since Ang-(1-7) induces opposite effects to those elicited by Ang II [16] [17] [18] [19] [20] [21] [22] [23] [24] . Additionally, ACE2 can form Ang-(1-7) less efficiently through hydrolysis of Ang I to Ang-(1-9) with subsequent Ang-(1-7) formation [24] .
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