Selected article for: "entry mechanism and viral genome"
Author: Bohmwald, Karen; Gálvez, Nicolás M. S.; Ríos, Mariana; Kalergis, Alexis M.
Title: Neurologic Alterations Due to Respiratory Virus Infections
  • Document date: 2018_10_26
    • ID: 0rlotyz3_19
    Snippet: To give more insights about this phenomenon, Espinoza et al. (2013) evaluated the neuro-invasive ability of hRSV in a mice model performing an intranasal inoculation that differs in the methodology used in the 60s. Importantly, the authors observed that viral genome and proteins could be detected in the brain of the infected mice, mainly in cortex, hippocampus and ventromedial hypothalamic nucleus (VMH) at 3 days post-infection (Espinoza et al., .....
    Document: To give more insights about this phenomenon, Espinoza et al. (2013) evaluated the neuro-invasive ability of hRSV in a mice model performing an intranasal inoculation that differs in the methodology used in the 60s. Importantly, the authors observed that viral genome and proteins could be detected in the brain of the infected mice, mainly in cortex, hippocampus and ventromedial hypothalamic nucleus (VMH) at 3 days post-infection (Espinoza et al., 2013) . Later they evaluated a possible route of entry for hRSV into the brain-the Trojan horse mechanism-by using a blocking antibody for CD49d, which is expressed by leukocytes and is required for transendothelial transmigration of this cells (Espinoza et al., 2013 ; Figure 1 ). The results obtained showed a decrease of viral load in the brain of hRSV-infected mice previously treated with anti-CD49d, suggesting that this can be the entry route used by hRSV (Espinoza et al., 2013) .

    Search related documents:
    Co phrase search for related documents
    • block antibody and mice model: 1
    • entry possible route and possible route: 1, 2, 3, 4, 5, 6, 7, 8
    • entry route and intranasal inoculation: 1
    • entry route and possible route: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10
    • infected mouse and intranasal inoculation: 1, 2
    • infected mouse and mice model: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12
    • infected mouse brain and mice model: 1
    • intranasal inoculation and mice model: 1, 2, 3, 4, 5, 6, 7, 8