Author: Colino, Clara I.; Millán, Carmen Gutiérrez; Lanao, José M.
Title: Nanoparticles for Signaling in Biodiagnosis and Treatment of Infectious Diseases Document date: 2018_5_31
ID: 1bxwb2hj_98
Snippet: Metallic nanoparticles have been demonstrated to improve HIV-1 p24 antigen assay. Nanoarrays obtained by nanolithography have shown an enhancement in the detection limit as well as faster detection than the conventional colorimetric enzyme-linked immunosorbent assay (ELISA) [75] . A microchip based on microfluidics and nanoparticles has been developed which allows diagnosis on-site of both HIV and syphilis. This device replicates the ELISA steps .....
Document: Metallic nanoparticles have been demonstrated to improve HIV-1 p24 antigen assay. Nanoarrays obtained by nanolithography have shown an enhancement in the detection limit as well as faster detection than the conventional colorimetric enzyme-linked immunosorbent assay (ELISA) [75] . A microchip based on microfluidics and nanoparticles has been developed which allows diagnosis on-site of both HIV and syphilis. This device replicates the ELISA steps and allows the detection of antibody markers within scarcely few minutes at low cost, with enough sensitivity and specificity and requiring just a few microliters of blood sample. Thus, this mChip miniaturizes ELISA techniques and, implemented in a handheld instrument easy to operate, provides a fast and affordable assay that can be used in the most remote regions [118] .
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