Selected article for: "cellular machinery and host cellular machinery"
Author: Ojosnegros, Samuel; Beerenwinkel, Niko
Title: Models of RNA virus evolution and their roles in vaccine design
  • Document date: 2010_11_3
    • ID: 0q928h3b_1
    Snippet: Viruses are intracellular parasites that need the cellular machinery of the host to reproduce [1] . They have the potential to generate huge population sizes in short generation times. Viruses in general, and RNA viruses in particular, exist in genetically heterogeneous populations because of their error-prone replication [2] . These features make the evolution of viruses a phenomenon observable on short time scales of weeks to months. The conseq.....
    Document: Viruses are intracellular parasites that need the cellular machinery of the host to reproduce [1] . They have the potential to generate huge population sizes in short generation times. Viruses in general, and RNA viruses in particular, exist in genetically heterogeneous populations because of their error-prone replication [2] . These features make the evolution of viruses a phenomenon observable on short time scales of weeks to months. The consequences of the extreme viral evolutionary dynamics are of tremendous importance for disease control and prevention. For example, influenza vaccines need to be updated every year, viral variants develop resistance to antiviral drugs, and mild viral strains turn into virulent ones spontaneously. These global health care issues and others arise from the rapid evolution of viruses.

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