Selected article for: "gag cleavage and multimerization capacity"
Author: Pan, Yen-Yu; Wang, Shiu-Mei; Huang, Kuo-Jung; Chiang, Chien-Cheng; Wang, Chin-Tien
Title: Placement of Leucine Zipper Motifs at the Carboxyl Terminus of HIV-1 Protease Significantly Reduces Virion Production
  • Document date: 2012_3_1
    • ID: 09locmnw_19
    Snippet: Despite a lack of direct evidence, it is generally accepted that Gag-Pol molecule dimerization or multimerization triggers HIV-1 PR activation, which mediates Gag and Gag-Pol cleavage. Here we demonstrated that the insertion of LZ at the C-terminus of PR triggers markedly enhanced PR-mediated Gag cleavage efficiency, which is associated with increased Gag-PR multimerization capacity. This suggests that an HIV-1-unrelated protein sequence capable .....
    Document: Despite a lack of direct evidence, it is generally accepted that Gag-Pol molecule dimerization or multimerization triggers HIV-1 PR activation, which mediates Gag and Gag-Pol cleavage. Here we demonstrated that the insertion of LZ at the C-terminus of PR triggers markedly enhanced PR-mediated Gag cleavage efficiency, which is associated with increased Gag-PR multimerization capacity. This suggests that an HIV-1-unrelated protein sequence capable of self-association can enhance Gag cleavage efficiency when fused to the PR C-terminus. It also provides evidence in support of the assumption that Gag-Pol/Gag-Pol interaction triggers PR activation.

    Search related documents:
    Co phrase search for related documents
    • cleavage efficiency and Gag cleavage efficiency: 1, 2, 3, 4, 5, 6, 7
    • cleavage efficiency and Gag Pol cleavage: 1
    • cleavage efficiency and Gag PR multimerization capacity: 1, 2
    • cleavage efficiency and LZ insertion: 1
    • cleavage efficiency and multimerization capacity: 1, 2
    • cleavage efficiency and pr activation: 1, 2
    • cleavage efficiency and pr activation trigger: 1
    • cleavage efficiency and pr trigger: 1
    • cleavage efficiency and protein sequence: 1, 2, 3
    • direct evidence and evidence provide: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73
    • direct evidence and protein sequence: 1, 2
    • direct evidence lack and evidence provide: 1
    • evidence provide and protein sequence: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14
    • evidence provide and self association: 1, 2, 3, 4, 5, 6
    • Gag cleavage efficiency and LZ insertion: 1
    • Gag cleavage efficiency and multimerization capacity: 1, 2
    • Gag cleavage efficiency and pr activation: 1, 2
    • Gag cleavage efficiency and pr activation trigger: 1
    • Gag cleavage efficiency and pr trigger: 1