Author: Jiang, Yuting; Zhao, Guangyu; Song, Nianping; Li, Pei; Chen, Yuehong; Guo, Yan; Li, Junfeng; Du, Lanying; Jiang, Shibo; Guo, Renfeng; Sun, Shihui; Zhou, Yusen
Title: Blockade of the C5a–C5aR axis alleviates lung damage in hDPP4-transgenic mice infected with MERS-CoV Document date: 2018_4_24
ID: 0kihygau_43
Snippet: In summary, our study demonstrated that MERS-CoV infection can result in a dysregulated host immune response, which then contributes to the severe outcomes observed after infection. However, blockade of the C5a-C5aR interaction could alleviate tissue damage induced by MERS-CoV infection through the regulation of the host immune response, especially the apoptosis and regeneration of T cells in spleens. Our study suggests a new effective clinical i.....
Document: In summary, our study demonstrated that MERS-CoV infection can result in a dysregulated host immune response, which then contributes to the severe outcomes observed after infection. However, blockade of the C5a-C5aR interaction could alleviate tissue damage induced by MERS-CoV infection through the regulation of the host immune response, especially the apoptosis and regeneration of T cells in spleens. Our study suggests a new effective clinical intervention and adjunctive treatment for MERS-CoV infection.
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